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Despite these advances, nutritional supplementation of antioxidants remains as a controversial strategy for cancer cachexia treatment due to incomplete understanding of mechanisms of action and potential side effects

A recent study using dextran sulfate sodium salt-induced colitis mice demonstrated that an enrichment in beneficial microbes, including Lactobacillus, Akkermansia , and Faecalibaculum , as well as elevated production of butyrate from the gut, and upregulated ZO-1 and OCLN levels in the BBB, enhancing its barrier function [240]

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lipoic acid is thought to be expected to work to prevent diabetes (type 2)