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While supplements can be an easy and convenient way to bump up your intake of certain vitamins and minerals that you may lack, results from some intervention studies show that use of single micronutrient supplements is unlikely to produce a lowering of disease risk factors, but an overall nutrient-dense diet can

For beginners, a 0.5-1% concentration applied two to three times weekly provides a gentle introduction

Discontinue use if you experience any adverse reactions, and consult a healthcare professional if symptoms persist

The simplest way is to focus on the three vitamin B12 forms and pathways through which the vitamin functions: Methylcobalamin works in the cell plasma Adenosylcobalamin functions in the mitochondria Hydroxocobalamin takes effect in the blood and cell plasma Methylcobalamin and adenosylcobalamin are known as the bioactive coenzymes of vitamin B12: only in these chemical forms can the vitamin be directly utilised in the body

Oxidative stress is also reported to be an important pathological phenomenon that begins to appear early in the course of AD (Saito et al., 2019)