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doi: 10.5772/INTECHOPEN.1008509 169 Snchez-BayuelaDCastellanoRAnguloAGiovanetti GonzlezPMCruz HernndezRRuizLMet al

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

It has been shown that ROS builds up in the gastric carcinoma cells after exposure to 5-FU activates HIF-1-(HMGB1) signaling, which recruits M2 TAMs, which generates GDF15 (growth differentiation factor 15), and enhances fatty acid -oxidation thus increasing the chemoresistance in them [278]

Polycystic Ovary Syndrome (PCOS) - 5-10% of women 50% lower glutathione levels compared to women without PCOS 3-4x higher risk of preeclampsia 3x higher risk of gestational diabetes Critical concern: With 50% lower baseline glutathione, the "safe" dose is effectively cut in half IVF Conception - 2-5% of births (up to 6-8% in some countries) Women who conceive via IVF experience dramatic antioxidant depletion: 70% reduction in plasma antioxidant capacity 83% reduction in follicular fluid antioxidant capacity 50-100%+ increase in oxidative stress markers With over 5 million babies born via IVF globally, this represents a large high-risk population Gallbladder Dysfunction - 10% of pregnant women Up to 10% develop gallstones or biliary sludge Intrahepatic cholestasis: 0.4-10% of pregnancies CRITICAL: Fatal Outcomes Documented at Therapeutic Doses The first case of a pregnant woman with intrahepatic cholestasis who died from liver failure after taking THERAPEUTIC/NORMAL doses of acetaminophen was reported in 2022

Self-adapting wettability of ReS2 under a constant stimulus