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10.1016/j.bbrc.2017.07.087 138 TakahashiR.KandaT.KomatsuM.ItohT.MinakuchiH.UraiH.et al (2022)

The Phase 2b trial (PMID: 23714218) failed to demonstrate significant weight loss compared to placebo over 12 weeks, despite adequate sample size and dosing