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Its levels within a cell must be tightly regulated, as deficiencies can lead to apoptosis and a surplus can lead to toxic build-up of reactive oxygen species produced via the Fenton reaction (Thomas et al

Its antioxidant activity tends to act in dual ways: first it attacks ROS and prevents the formation of lipid peroxides, and second, it can replenish and regenerate other antioxidants like vitamin C and E (Haleagrahara et al

This adhesion enables fibroblasts to spread and exert mechanical forces on the surrounding ECM, maintaining a "youthful" phenotype characterized by the preservation of ECM composition and structural organization

Biochem Pharmacol 195:114842