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Research confirms that in uterine fibroid tissue, the accumulation level of the oxidative damage marker 8-OHdG shows a significant positive correlation with MED12 mutation status, suggesting that an OS environment may represent a key selective pressure driving MED12 hotspot mutations [Citation112]

Among the differentially expressed genes, transcripts related to thyroid function were up-regulated (Fig S6A) whereas Nrf2 target genes and Nrf2 regulating genes were shown down-regulated (Fig S6A and D) (Raghunath et al, 2018)