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The discovery of cuproptosis by Tsvetkov P and colleagues emphasizes the regulatory mechanism of positive regulatory factors FDX1, lipoylated proteins (LIPT1, LIAS, DLD), lipoylated targets (DLAT, PDHA1, PDHB), negative regulatory factors GLS, CDKN2A, MTF1 and mitochondrial metabolism (lipoylated pathway, TCA cycle) in Cu-induced cell death (Tsvetkov et al., 2022)

Cancer Biol Ther 12:10851097 Konishi H, Karakas B, Abukhdeir AM, Lauring J, Gustin JP, Garay JP, Konishi Y, Gallmeier E, Bachman KE, Park BH (2007) Knock-in of mutant K-RAS in nontumorigenic human epithelial cells as a new model for studying K-RAS mediated transformation

XIST knockdown downregulated AQP5 and occludin expression and upregulates SSB expression in SGECs (Fig

The transsulfuration pathway has a very limited tissue distribution

Austin, G