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Since eNOS was cloned (Marsden et al., 1992), our understanding of how NO availability is regulated has increased exponentially

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Get the escalation wrong, and the gastrointestinal side effects become severe enough that people abandon the protocol entirely

One of the treatments utilising corticosteroids is effective in controlling the symptoms, but cannot be used for the long term due to the side effects that include effects on weight, bone mass and blood pressure

An intriguing but relatively underexplored mechanism for modulating microglial activation is the transient receptor potential melastatin 2 (TRPM2) channel [6]