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Hu, M., Wang, D., Tang, X., Zhang, Q., Zhao, J., Mao, B., Zhang, H., & Cui, S

10.1016/j.biopha.2022.113555 342 SharmaS.de VriesE

Reactive oxygen species (ROS), in excess, can cause disruption to normal cellular function and can damage cells (in particular mitochondria, & DNA of the sperm and egg) and tissues

These cell lines were cultured in a 5% CO2 incubator at 37 C

Additionally, certain medications and genetic predispositions can increase susceptibility to developing hyperpigmentation, making it a multifaceted concern requiring targeted treatment approaches