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However, prolonged or high-dose ketamine exposure induces a compensatory upregulation of NMDARs, increasing intracellular calcium ion influx and ROS production, ultimately leading to neuronal apoptosis ( In animal studies, antagonism of NMDA receptors in intermediate neurons of the forebrain and thalamus reduces GABAergic function

A high extraction ratio inevitably leads to low oral bioavailability

Casagrande, F

Published online November , 3

Int J Bioassays 4(1):36543656 Yahya H, Yahya KM, Saqib A (2011) Minerals and type 2 diabetes mellituslevels of zinc, magnesium and chromium in diabetic and nondiabetic population