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These protective effects on ER stress activation were abolished in VKORC1L1-silenced, but not VKORC1-silenced, cells (Figure S6I S6J)

To assess the additive effect of co-encapsulated PTX and aPD-L1 delivered into the brain, the antitumor efficacy of free aPD-L1 and free PTX and A2-APM were examined in GL261 and G422 tumor mice (Supplementary Fig