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Thus, AR dimerization utilized tunable surfaces that are important for interdomain allostery and were found to be particularly important to bind degenerate DNA sequences, providing an explanation for how AREs that deviate considerably from the optimal textbook sequence in CaP still lead to robust transcriptional outputs

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However, other factors may be involved, including accumulation of lactate, pyruvate, glutamine and free glucose, and depletion of glycogen, ketone bodies and glutamate