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Importantly, cilium assembly is enhanced at this stage, driven by the synergistic effect of E2 signaling activation and NOTCH signaling suppression, culminating in the upregulation of forkhead box J1 ( FOXJ1 ), a key transcription factor (TF) essential for ciliogenesis [19]

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Even on the 5th day of DSS administration, there were some areas where the rectal crypt structure and colon plicae did not collapse in the Si-DSS group, and no macrophages were observed in such areas

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