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346 In PDX models of thyroid cancer with different KRAS, BRAF, and NRAS mutations, the MEK inhibitor selumetinib combined with the MDM2 inhibitor KRT-232 showed a remarkable effect

Results KU-57788 induces mitotic catastrophe and cellular senescence in ATC cells The abnormal upregulation of DNA-PKcs in ATC tissues suggests that DNA-PKcs might be a critical protein for ATC cell division and proliferation (Fig