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Chitosan is pH-sensitive, as it is soluble at a low pH and insoluble at a high pH, rendering it highly applicable for controlled release systems (Treenate and Monvisade, 2017)

PubMed PMID: 38797357 Baker PR 2nd, Li AS, Griffin BR, Gil HW, Orlicky DJ, Fox BM, Park B, Sparagna GC, Goff J, Altmann C, Elajaili H, Okamura K, He Z, Stephenson D, D'Alessandro A, Reisz JA, Nozik ES, Sucharov CC, Faubel S

Proline suppresses rubisco activity by dissociating small subunits from holoenzyme

A well-run randomized Phase 2 study is strong evidence of an efficacy signal and a first read on short-to-medium-term safety in a selected population it is why the weight-reduction numbers are credible rather than anecdotal

One reason to doubt the link is that B 12 deficiencies are most common in people older than 50