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These experiments will generate the comparative efficacy data necessary to predict which histologic subgroups are most likely to benefit from specific hydrogel formulations and to inform stratified clinical trial designs

MM patients who progressed after daratumumab treatment had elevated levels of the complement inhibitors CD55 and CD59, in agreement with the hypothesis that CDC represents a major mechanism of action for daratumumab and suggesting a mechanism of resistance to CDC-mediating antibodies

doi: 10.1038/s41591-022-01923-y [DOI] [PMC free article] [PubMed] [Google Scholar] 41.Kang C