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Wolverine stack protocol: PDA: 500 mcg to 1 mg subcutaneous, once daily TB-500: 2.0 to 2.5 mg subcutaneous, 2 to 3 times weekly (loading phase), then once weekly (maintenance) Duration: 6 to 8 weeks Timing: PDA and TB-500 can be administered at the same time or at different times during the day

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Lipid regulation of OL responses As OLs extend up to 60 myelinated processes and can generate up to 50 10 3 m 3 of membrane per day, myelination and remyelination are highly demanding processes