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A daily combination of 1 mg of folate, 7.2 mg of vitamin B6, and 20 ug of vitamin B12 effectively reduced plasma homocysteine levels in these individuals.42 Many patients with inborn errors of metabolism that affect homocysteine metabolism, such as CBS deficiency, require a low-protein diet in which methionine-rich foods such as meat, fish, eggs, and dairy foods are restricted

To find sources of heterogeneity and explore the effect sizes, we carried out subgroup analyses based on some confounding factors

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However, challenges such as bioavailability, stability, and potential interactions with standard therapies remain