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Intracrine androgen synthesis may have led to restored AR signaling, leading to a rise in PSA levels and recurrent tumor growth, a relapsed state commonly referred to as castration-resistant prostatic cancer (CRPC) 8

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References Jett, L., Lger, R., Thibaudeau, K., Benquet, C., Robitaille, M., Pellerin, I., Paradis, V., van Wyk, P., Pham, K., & Bridon, D

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