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Macrophage polarization toward the M2 phenotype under stimuli can facilitate this process by promoting stem cell differentiation and extracellular matrix remodeling [426]

doi: 10.1038/s41579-020-0438-4 63 YamadaTHinoSIijimaHGendaTAokiRNagataRet al

During sepsis, pathogen invasion activates innate-immune sentinelsespecially macrophages and neutrophilswhich deploy reactive species such as superoxide (O), hydroxyl radical (OH), peroxynitrite (ONOO ) and hypochlorous acid (HOCl) to kill microbes (57)

[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Iciek M, Kwiecien I, Wlodek L

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