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Using a high-content phenotypic assay, researchers identified small molecules such as RH1115, which modulates autophagic flux by targeting proteins like Lamin A/C and LAMP1, promoting neuronal health and altering lysosome positioning for potential therapeutic benefit [140]

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This increases the Firmicutes / Bacteroidetes ratio, which is associated with obesity (158, 159)

doi: 10.1016/j.molcel.2018.10.042 18 PontelLBBueno-CostaAMorellatoAECarvalho SantosJRouGEstellerM