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iron nutrition and tumor growth: decreased tumor growth in iron-deficient mice

Yagasaki H, Takekoshi S, Kitatani K, Kato C, Yamasaki H, Shioyama K, et al

However, intense evidences suggest that lipid peroxidation can be the common feature that initiates and propagates the cell death

Recent studies have shown that, in mammalian cells, most of the active-site disulphides in the ER oxidoreductases are reduced under normal steady-state conditions (Jessop & Bulleid, 2004)

Even lower IC 50 s (higher sensitivity) have been reported using rat primary osteoblasts (IC 50 of 2 M for cadmium) [49], which may reflect species-specific effects as well as improved responsiveness of primary cells