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Opioid maintenance pharmacotherapies minimise opioid withdrawal and reduce the reinforcing effects of heroin, leading to a reduction in the use of illicit heroin [12, 13] and harms associated with illicit drug use (e.g

By contrast, inadequate PRLM production or persistent noxious stimuli disrupts the balance between proinflammatory and pro-resolving responses, fostering the transition from acute to chronic inflammation, perpetuating tissue damage, and accelerating disease progression [9]

Additional further testing of mutants in these detoxification systems in host infection models and global transcriptome analysis would be useful to determine how great of an extent they are required for overall survival

Dobrina A, Rossi F

doi: 10.1042/BSR20201807 120 ZhuangJLiuXYangYZhangYGuanG