doi:10.1182/bloodadvances.2020001830 Gmez-Outes A, Terleira-Fernndez AI, Lecumberri R, Surez-Gea ML, Vargas-Castrilln E
(1999) identified this novel protein, Kelch-like ECH-associated protein1 (KEAP1), as the cytosolic negative regulator of NRF2 activity
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Therefore, the methylation of NA catalyzed by NNMT is inhibited, and the product, MNA, is reduced
