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NPDs are often triggered by microglial activation, the production of pro-inflammatory cytokines, and disruptions to the blood-brain barrier (Pape et al., 2019)

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Pyruvate carboxylase (PC) is an anaplerotic enzyme essential for oxidative stress protection, although its relationship with GPX4 in obesity-related breast cancer is not established

Transcriptomic analyses of COPD AMs show increased expression of HIF-1 and its downstream targets, including the adenosine A 2 B receptor, a gene often upregulated under hypoxic or glycolytic conditions [82]