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It does this by taking a methyl group from 5-methyltetrahydrofolate (the active form of folate), transferring it back to the cobalamin, and releasing free tetrahydrofolate

D.MartinM.HouckK.BrowneP.et al (2017)

4 Effect of cysteine restriction on tissue GSH, serum GDF15 and FGF21 levels

for instance, this modification may alter the secondary structure, enhancing mRNA accessibility to nucleases, or the mRNA may possess sequences that facilitate premature degradation, such as AU-rich elements