glutathione peroxidase in lung cancer Frontiers glutathione peroxidase and lung cancer

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Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily

therefore, they are often referred to as glycotoxins and are particularly implicated in the development of noncommunicable chronic diseases, especially those associated with inflammation ( This review explores some aspects of the metabolism and digestion of glycotoxins by both human and microbial enzymes, highlighting how their interplay can balance the dual nature of these compounds and their impact on human health

identified creatine kinase B (CKB)-enhanced GPX4 as a novel mechanism for regulating ferroptosis, accounting for the resistance of HCC cells to ferroptosis by stabilized GPX4 via CKB phosphorylated GPX4 at residue S104