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FIGURE 1 Transcriptional regulation of eNOS The NOS3 gene is located on chromosome 7 (7q35-36) and is regulated by a promoter region containing binding sites for multiple transcription factors, including Krppel-like Factor 2 (KLF2), Specificity protein 1 (Sp1), Specificity protein 3 (Sp3), Ets1, mothers against decapentaplegic homolog-2 (Smad2), and Nuclear factor erythroid 2-related factor (Nrf2), among others (Karantzoulis-Fegaras et al., 1999

Moreover, we found elevated levels of IL-6 in the blood and lungs of patients and mice with PH

BioMed Rep (2016) 5(3):2838

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To solve this paradigm, using repurposed compounds with known BBB penetrance provides promising therapeutic opportunities for GBM, with a special focus on the design of combinational drugs that specifically target cancer cells while minimizing damage to healthy cells