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These results demonstrated that Chr1 went under extreme evolutionary events while Chr4 faced minimum evolutionary events (Figure 6 and Supplementary Table 4)

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3 However, fusion comes with significant drawbacks: Permanent loss of motion at the C7-T1 segment Adjacent segment disease : Increased stress on C6-C7 and T1-T2 discs above and below the fusion Hardware complications : Risks of plate migration, screw loosening, or pseudoarthrosis (failed fusion) Longer recovery : Typically 6-12 weeks before returning to normal activities Dysphagia risk : Difficulty swallowing affects 50% of patients immediately post-op, with 10-20% experiencing chronic symptoms Posterior Foraminotomy : Some surgeons perform this procedure from the back of the neck, removing bone to enlarge the foramen and decompress the C8 nerve