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VIP and immune cell modulation VIP interacts with multiple immune cells through specific receptors (VPAC-1, VPAC-2, CRTH2, and PAC1) expressed on eosinophils, mast cells, neutrophils, lymphocytes, dendritic cells, NK cells, and macrophages

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Despite the rapid turnover rates for most cell types present in the intestinal epithelium, Paneth cells have a life span of up to two months and play an important role in the defence against harmful microbes (Mu et al