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517,518,519,520,521,522 However, as the inhibitory effects of these agents have primarily been confirmed in vitro, extensive efforts are required to advance these drugs to clinical trials

Though these cancers are not a direct cause of B12 deficiency, B12 deficiency may be an initial presenting sign of an underlying malignancy when no other reason can be determined

Biol Psychiatry (2009) 65:73241.10.1016/j.biopsych.2008.11.029 213 SavitzJFrankMBVictorTBebakMMarinoJHBellgowanPSet alInflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities

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During the acute phase of sepsis, innate immune cells (such as macrophages and neutrophils) undergo a significant metabolic shift from efficient OXPHOS to inefficient but rapid aerobic glycolysis (the Warburg effect)