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Effects typically appear within 12 weeks (reduced pain, improved mobility)

Clear In states of excessive hydration, there can be a decrease in blood levels of sodium, which can have an impact on brain function, says Michael Whalen, MD, chief of urologic oncology at the George Washington University School of Medicine and Health Sciences in Washington, D.C

In addition, B12 deficiency-associated fatigue is often accompanied by other symptoms such as numbness and tingling, cognitive impairment (memory and concentration problems), mood swings (depression), skin changes (pale skin), shortness of breath, or fast heart rate

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