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World Health Organization (WHO) has estimated the occurrence of 11 million burn injuries per year globally, 180,000 of which can lead to death (Jeschke et al., 2020)

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Apocynin is a bioactive phenol extracted from the roots of Apocynum venetum L., and as a NOX2 inhibitor, it can prevent ROS production and reduce inflammatory responses (Philippens et al., 2013)