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Among the various compounds, the pomalidomide-based PROTAC 123 stands out with a potent T-cell killing capacity resulting from the forced depletion of the target protein in a dose- and time-dependent manner

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As demonstrated, silencing either EAAT3 or P65 led to the accumulation of ROS (Fig

Parasitol., 32, 1133-1143 10

Along with a change in the profile of sulfur-containing metabolites, in cells that have lost ADP-heptosis, an increase in the level of generation of reactive oxygen species (ROS) is observed, accompanied by the depletion of NADPH reducing equivalents