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When you take sermorelin, it travels to your pituitary gland and binds to specific receptors

Research models suggest it may interact with: GLP-1 receptors GIP receptors glucagon receptors This additional glucagon receptor activity is one of the major distinctions researchers evaluate when comparing Retatrutide vs Tirzepatide

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That being said, because IGF variants frequently increase permanent lean muscle mass via hyperplasia, your basal metabolic rate (how many calories you burn naturally at rest) is typically elevated permanently, making it easier to stay leaner year-round moving forward