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Gln metabolism and PPP are tightly interconnected: Gln deprivation activates G6PD, whereas a loss of G6PD function activates glutaminolysis in cancer cells [81,82]

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Overexpression of MAPKAPK2 effectively alleviated key pathological features, including ROS accumulation, impaired melanogenesis, and increased apoptosis, potentially via KEAP1/Nrf2/HO-1 signaling activation

Collectively, these findings highlight the potential of amino acids such as arginine, proline, glutamate, methionine, cysteine, glutamine, and BCAAs as novel biomarkers for IPF diagnosis, disease staging, and progression monitoring

This medication will be given only when the vitamin B 12 deficiency is established