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Distinct serum and tumor cytokine profiles were observed, including intratumoral downregulation of vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1 alpha (HIF-1), c-MET, interleukin-10 (IL-10), Ki67, and tumor necrosis factor alpha (TNF-)

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While some practitioners may choose localized injections in certain situations, the injection site itself is not always the primary factor determining results

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Many modifications of the 45S5 have followed