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doi: 10.1016/j.ejmech.2018.08.062

Hatfield DL, Yoo MH, Carlson BA, Gladyshev VN

FOXO4-DRI is a large peptide (~5382 Da, 48 amino acids) with a critical structural modification: the D-Retro-Inverso (DRI) design uses D-amino acids in reversed sequence to confer protease resistance while maintaining the 3D spatial arrangement needed for target binding

the use of any combination reduces inflammatory biomarkers and improves the symptoms (Global Initiative for Asthma, 2020)

Result Repeated intraperitoneal injections of nitroglycerin induced migraine-like behavior in mice Based on previous reports, we established a chronic migraine-like model in male mice by administering intraperitoneal injections of nitroglycerin at a dose of 10 mg/kg every other day(Fig