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This is still unclear and will require more studies to grasp what IGF-1 LR3 can and cannot do in this scenario

doi: 10.1111/j.1528-1167.2010.02577.x [DOI] [PMC free article] [PubMed] [Google Scholar] 152.Karimzadeh F, Jafarian M, Gharakhani M, Razeghi Jahromi S, Mohamadzadeh E, Khallaghi B, et al

In addition to the ubiquitous expression of the IGFs, these growth factors circulate in high concentrations and, because of the rich blood supply of the cortical and trabecular skeleton, allow exposure of bone cells to these peptides

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