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This was a 15-year-old boy who presented with mental retardation, mild motor impairment, and partial deafness

Similarly, targeted Treg depletion exacerbated WD-induced hepatic inflammation and fibrosis

[17] Cellular iron regulation [edit] Iron import [edit] Most cell types take up iron primarily through receptor-mediated endocytosis via transferrin receptor 1 (TFR1), transferrin receptor 2 (TFR2) and GAPDH

doi: 10.3390/toxins5040605

ROS generated during oxidative stress can activate the IB kinase (IKK) complex, which phosphorylates IB proteins and marks them for ubiquitin-mediated degradation