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For females, the age-adjusted prevalence of hyperpigmentation rose from 0.3 per 100 in the lowest exposure category to 11.5 per 100 in the highest exposure category

Chem Biodivers 16(10):e1900341 ArasHisar , Hisar O, Beydemir , Glin , Yank T (2004) Effect of vitamin E on carbonic anhydrase enzyme activity in rainbow trout ( Oncorhynchus mykiss ) erythrocytes in vitro and in vivo

Pharmacotherapies that target these more protracted changes have the potential to greatly improve both treatment retention and functional outcomes during recovery

Uversky, 1994)

The high dose of cyanocobalamin is generally well-tolerated due to the vitamins water-soluble nature and efficient excretion of excess amounts