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Appl Biochem Biotechnol 173(2):552561

Animal studies confirm that AS-IV exhibits no evident toxicity or adverse effects within a safe dose range, equivalent to 3570 times the human dose (Yu et al., 2007)

This rerouting may appear counterintuitive, but it reflects the unique priorities of erythrocytes, which do not require mitochondria to function but must respond quickly to oxygen fluctuations