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Under these conditions, HIFs are activated and promote the expression of various genes that lead to tumor vascularization, epithelialmesenchymal transition (EMT), invasion/metastasis, cancer-specific metabolism, immune escape, and cancer stem cell (CSC) trait acquisition

Moreover, recruited neutrophils during the inductions inflammatory phase (first week) will further participate in tissue injury and fibrosis by producing matrix-degrading enzymes such as neutrophil elastase and releasing excessive ROS 12