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A previous study showed that simvastatin changed the composition of gut microbiota in rats fed with HFD and caused an elevation in Ruminococcaceae and Lactobacillus levels (113)

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Direct provision of TMAO into diet has been shown to increase the development of atherosclerosis in animal models, confirming its pro-atherogenic properties 47 and multiple clinical studies have confirmed that an elevated TMAO level is associated with increased risks for incident major adverse CV events 48