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COX-1 induction leads to a substantial increase in thromboxane A2 (TXA 2 ) in human endothelial cells, while induction of COX-2 by IL-1B leads to a minor increase in TXA 2 but a substantial induction of the proinflammatory proteins prostacyclin (PGI 2 ) and prostaglandin E2 (PGE 2 ) (232)