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The main roles for PGEs and PGI 2 in inflammation may in fact be in the generation of hyperalgesia, sensitization of the tissue to the irritant and pain producing activity of the amine and peptide type of mediators of inflammation (Ferreira and Nakamura, 1979

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In contrast, using targeted treatments for Fusobacterium , such as metronidazole or berberine, would be the recommended root cause approach