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GH stimulates the production of ammonia in canine renal proximal tubule segments, suggesting that it may be a regulator of net acid secretion [76]

Dihexa targets synaptic remodeling through HGF/c-Met signaling, a fundamentally different mechanism, but it has never been tested in human clinical trials and lacks the safety data, dosing guidelines, and efficacy proof required for FDA approval

Nat Chem Biol 18:109115

Yao M, Tabuchi H, Nagashima Y, Baba M, Nakaigawa N, Ishiguro H, Hamada K, Inayama Y, Kishida T, Hattori K (2005) Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma