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Despite these insights, the precise role of macrophages in the pathogenesis of acne remains poorly elucidated

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Of note, while a central role for HIF1 in macrophage glycolysis can be appreciated from aforementioned, silencing of HIF1 or HIF2, or exaggerated HIF signaling by knockdown of its upstream regulators has many other cellular effects that complicate its use as intervention in atherosclerosis (Marsch et al., 2014

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Metabolite-derived redox regulators such as glutathione and ascorbate modulate ER-associated stress, representing a biochemical parallel to nitrosative stress mechanisms in animals