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Moreover, PGC-1 is involved in autophagy [47, 48], and may regulate mitophagy by the PINK1-Parkin dependent [49, 50] and independent pathways [51, 52]

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dFmr null mutant fly) and patients over the years, an approved and successful curative therapy for FXS is missing to date, and the management of the clinical aspects of the syndrome continue to focus on symptomatic treatment of psychiatric and behavioral problems, rather than the molecular causes ( Table 1 Treatments for Fragile X syndrome