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For example, an interoceptive dopaminergic circuit allows Drosophila to reject an incomplete diet lacking essential amino acids 1

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A recent study in mice additionally showed that the gut microbiome plays an important role in endogenous NAD + biology, where circulating NAM and oral NR are converted to NA which, in turn, are reabsorbed into the circulation as a precursor for the Priess-Handler pathway (27)

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